Between Signaling Pathways

• Wnt/Wingless and TGF-beta/BMP
1. Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression.
2. Wnt and TGF-beta signalling pathways during formation of Spemann's organizer
3. Smad3/APC/RB
4. Wnt,TGF-beta and Hedgehog
5. Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development.
6. Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways.
7. Patterning of the mesoderm involves several threshold responses to BMP-4 and Xwnt-8.
8. Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J).
9. Successive formative stages of precartilaginous mesenchymal condensations in vitro: modulation of cell adhesion by Wnt-7A and BMP-2.
10. Jonathan M. (Jon) Graff, M.D., Ph.D.
• Wnt/Wingless and Notch
1. Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?
2. Disturbance of Notch-1 and Wnt signalling proteins in neuroglial balloon cells and abnormal large neurons in focal cortical dysplasia in human cortex.
3. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly.
4. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion.
5. Modulation of wingless signaling by Notch in Drosophila.
6. Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
7. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
8. Jan Kitajewski, PhD
9. CHENG-MING CHUONG, M.D., Ph.D.
• Wnt/Wingless and Hedgehog
1. Suppressor of fused negatively regulates beta-catenin signaling
2. Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites.
3. Zebrafish wnt4b expression in the floor plate is altered in sonic hedgehog and gli-2 mutants.
4. Coordinate actions of BMPs, Wnts, Shh and Noggin mediate patterning of the dorsal somite
5. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
6. Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning
7. Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J).
8. Matthew Scott
9. Dr. Stephen Ekker
10. CHENG-MING CHUONG, M.D., Ph.D.
11. JEAN-PIERRE SAINT-JEANNET
12. Chi-chung HUI, PhD
• TGF-beta/BMP and Hedgehog
1. Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J).
2. The molecular basis of lung morphogenesis.
3. Cerberus regulates left-right asymmetry of the embryonic head and heart.
4. Hedgehog signaling molecules in bone marrow cells at the initial stage of fracture repair.
5. Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs.
6. Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs
7. Dynamo, a new zebrafish DVR member of the TGF-beta superfamily is expressed in the posterior neural tube and is up-regulated by Sonic hedgehog.
8. A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ
9. A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
10. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin.
11. Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells.
12. Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo.
13. Chi-chung HUI, PhD
14. CHENG-MING CHUONG, M.D., Ph.D.
15. Marnie Halpern
16. LHRI -> Investigator Profiles

Between Receptors

• Estrogen receptor and Progesterone receptor
1. Mechanisms of action and cross-talk between estrogen receptor and progesterone receptor pathways.
2. Differential cross-talk of estrogen and growth factor receptors in two human mammary tumor cell lines.
3. Estrogen receptors: bioactivities and interactions with cell signaling pathways.
4. Estrogen and progesterone receptors in the endometrium.
5. Inhibitory cross-talk between steroid hormone receptors: differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist-and antagonist-occupied progestin receptors.
6. progestnet.com/
7. Estrogen, Progesterone, and the Lipid Profile
8. Tips To Help You Cope With PMS
9. Birth Control Problem Set
10. About Estrogen, Memory and Menopause
• Angiotensin II Receptor: between AT1 and AT2 Receptors
1. Angiotensin II AT2 subtype receptors: an emerging target for cardiovascular therapy
2. Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family.
3. Modulation of the AT2 subtype receptor gene activation and expression by the AT1 receptor in endothelial cells.
4. Distribution and functional significance of angiotensin-II AT1- and AT2-receptor subtypes in the rat adrenal gland.
5. Pathophysiological function of angiotensin II AT1 and AT2 receptors and clinical application of AT1 antagonists
6. Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in adult human renal cortex using in situ hybridization.
7. Angiotensin II receptor subtype AT1 and AT2 expression after heart transplantation.
8. Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats.
9. Functional interactions between neuronal AT1 and AT2 receptors.
10. Advanced Bioconcept - Fluo-angiotensin II™
11. Cardiovasc Res
12. Research of Dr. Naima Moustaid-Moussa
• G(q/11) protein- and G(i/o) protein-coupled receptors
• Androgen receptor and vitamin D receptor
1. Androgen receptor and vitamin D receptor in human ovarian cancer: growth stimulation and inhibition by ligands.
2. Polymorphisms in the vitamin D receptor gene and the androgen receptor gene and the risk of benign prostatic hyperplasia.
3. Suggestive linkage of the parathyroid receptor type 1 to osteoporosis.
4. No association between androgen or vitamin D receptor gene polymorphisms and risk of breast cancer.
5. Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor alpha- and beta-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells.
6. Links between genetic and environmental factors and prostate cancer risk.
7. Polymorphisms of androgen and vitamin D receptor genes and the risk of breast cancer
8. ANTIBODIES FOR IMMUNOSTAINING OF CELLULAR ORGANELLES & STRUCTURES
9. Association of Prostrate Cancer Risk with Genetic Polymorphisms in Vitamin D Receptor and Androgen Receptor
10. Mark D. Nichols, Ph.D.
• Gq- and Gs-coupled heterotrimeric GTP-binding protein-coupled receptor
1. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.
• Chemokine receptors and epidermal growth factor receptor (EGF)
1. Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells.
2. IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity.
3. Bleomycin stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activities.
4. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.
5. Thrombin aivation of the 9E3/CEF4 chemokine involves tyrosine kinases including c-src and the epidermal growth factor receptor.
6. Cytokine-induced expression of transforming growth factor-alpha and the epidermal growth factor receptor in neonatal skin explants.
7. Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway.
8. ROZAKIS-ADCOCK, MARIA, Ph.D.
9. Peter S. Reinach, Ph.D.
10. Jeffrey D. Laskin, Ph.D.
11. PAUL W. COOK

Receptor and others

• Epidermal growth factor (EGF) receptor and c-Met
1. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
2. Genetic profile of gliosarcomas.
3. STAT 1alpha/1beta, STAT 3 and STAT 5: expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes.
4. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat.
• FGF-receptor tyrosine kinase and G-protein
1. The beta(2)-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor.
2. Shedding of syndecan-1 and -4 ectodomains is regulated by multiplesignaling pathways and mediated by a TIMP-3-sensitive metalloproteinase.
3. Rab7: a key to lysosome biogenesis.
4. Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
5. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity.
• Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A
1. Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.
2. Transcriptional cross-talk, the second mode of steroid hormone receptor action.
3. Mechanism of interaction between the glucocorticoid receptor and Stat5: role of DNA-binding.
4. AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor.
5. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue.
6. Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells.
• Gamma-aminobutyric acid A (GABA) receptors and dopamine D5
• FGF receptor and N/E-cadherin

Between Kinases

• Receptor tyrosine-kinase (RTK) and Serine-threonine kinases (RSK)
• protein kinase C (PKC), cAMP and mitogen-activated protein (MAP) kinases
• p38 MAP kinases and extracellular signal-regulated kinase (ERK)

Kinase and others

• Phosphatidylinositol 3-kinase (PI3K) and Sphingomyelinase
• protein kinase B (PKB) and the Raf-1 and NF-kappaB
• cyclic GMP-dependent protein kinase (PKG) and regulators of G protein-signaling (RGS)
• protein kinase C (PKC) and signal transducer and activator of transcription-6 (Stat6)
• MAP kinases and Wnt signalling pathway
• Receptor tyrosine-kinase (RTK) and TGF beta-like pathways

Sonic Hedgehog | TGF-beta | MAPK | NCBI